Talk:Creutzfeldt-Jakob disease

From Academic Kids

Is it possible that this disorder is related to Huntington's Corea the systoms are quite simliar, i have several family members that are dieing from this disorder, it is only confined to one set of gene pool it has been noted that the spouse that doesnt carry this defect watches their other spouse die and then watch their children, and if they were married at a very early age as in the old time of exceptable marriages ages these spouse also watched their grand children die as well .....

Probably not - Cretzfeldt-Jakob disease is caused by prions; as you noted, Huntington's is genetic. Both are neurodegenerative disorders, however, and some of the effects can be similar in two diseases with widely different causes. -- Sayeth 22:38, Oct 4, 2004 (UTC)
There has been some speculation that prion diseases are exacerbated by a faulty PrP gene. However, this is very, very rare and not linked to Huntington's disease in any way. -- FirstPrinciples 14:28, Oct 6, 2004 (UTC)

Huntington's and prion diseases, as well as things like Alzheimer's and Parkinson's, are all linked in a way because they are all protein misfolding diseases, i.e. a protein changes shape and that altered shape seems to cause damage to the brain. The differences between them are in which protein changes shape and what causes that change. Huntington's is caused by a genetic mutation where a particular bit is repeated over and over. This isn't what causes prion diseases like CJD, it is something else that changes the protein's shape and usually there is no mutation at all. Prion diseases are also unique because the abnormal protein is infectious.--Purple 01:08, 28 May 2005 (UTC)

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